Updated: Dec 9, 2020
The omega-3 PUFA EPA and DHA are important throughout life and are a dietary necessity found predominantly in fish and fish-oil supplements. The omega-3 fatty acids EPA and DHA are essential for proper fetal development, and supplementation during pregnancy has also been linked to decreased immune responses in infants including decreased incidence of allergies in infants. Omega-3 fatty acid consumption has been associated with improved cardiovascular function in terms of anti-inflammatory properties, PAD, reduced major coronary events, an improved antiplatelet effects in the face of aspirin resistance or clopidogrel hypo responsiveness. Patients with AD are deficient in DHA, and supplementing them with EPA +DHA not only reverses this deficiency but may also improve cognitive functioning in patients with very mild AD. With increasing rates of pediatric allergies, cardiovascular disease, and AD in the United States, EPA and DHA may be a safe and inexpensive link to a healthier life. Further research should be conducted in humans to assess a variety of clinical outcomes including quality of life and mental status. Also, because potent lipid mediator metabolites of EPA and DHA are of great interest currently, their influence on these important outcomes should be assessed because current evidence suggests that their anti-inflammatory and tissue-protective effects are nearly 1000 times greater than those of EPA and DHA.
The benefits of omega-3 supplementation are being investigated and successful results for several other conditions, including depression, inflammatory bowel disease, attention-deficit/hyperactivity disorder (ADHD), childhood allergies, and cystic fibrosis were observed.
recommendations from the Dietary Guidelines for Indian s: The 2015–2020 Dietary Guidelines for Indian s states that strong evidence from mostly prospective cohort studies but also randomized controlled trials have shown that eating patterns that include seafood are associated with reduced risk of CVD . Also, consuming about 8 ounces per week of a variety of seafood that provides about 250 mg per day EPA and DHA is associated with fewer cardiac deaths in both healthy individuals and those with preexisting CVD.
(PDF) A Review on Potential Properties and Therapeutic Applications of DHA and EPA. Available from: https://www.researchgate.net/publication/337745268_A_Review_on_Potential_Properties_and_Therapeutic_Applications_of_DHA_and_EPA [accessed Feb 15 2020].