COXINIP - TH

Etoricoxib  
Thiocolchicoside

Coxinip-TH Tablet is a combination of two medicines used in the treatment of pain due to muscle spasm. It improves the movement of muscles and provides relief from pain and discomfort associated with muscle spasms.

 

Introduction

Coxinip-TH Tablet is a combination of two medicines used in the treatment of pain due to muscle spasm. It improves the movement of muscles and provides relief from pain and discomfort associated with muscle spasms.


Coxinip-TH Tablet can be taken with or without food. You should take it regularly as advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.

Some of the common side effects of this medicine include diarrhea, stomach pain, indigestion, flatulence, swellings of hands and feet, and flu-like symptoms. If any of these side effects bother you or do not go away with time, you should let your doctor know. Your doctor may help with ways to reduce or prevent these side effects.


The medicine may not be suitable for everybody. Before taking it, let your doctor know if you have any problems with your heart, kidneys, and liver. To make sure it is safe for you, let your doctor also know all the other medicines you are taking. Pregnant and breastfeeding mothers should first consult their doctors before using the medicine.


Before knowing its combination, we should need to know that how they work individually, so you know that Etoricoxib is Anti-inflammatory medicines (NSAIDs), used to relieve pain, swelling, and other symptoms of inflammation and Thiocolchicoside (TCC) is used clinically for its muscle relaxant, anti-inflammatory, and analgesic properties. 

 

INDICATION AND USAGE:

It is used medically to treat orthopedic, traumatological and rheumatologic disorders as well as to treat muscular spasms.


It is also used to control the pain and swelling suffered by individuals with four medical conditions:


Rheumatoid arthritis : Rheumatoid arthritis is a disorder in which joint cartilage becomes inflamed and, over time destroyed.


Gout : Gout is a condition in which uric acid crystals accumulate within the cartilage of joints, resulting in extreme pain and inflammation.


Osteoarthritis : Osteoarthritis concerns the gradual and irreversible degradation of the cartilage located within bone joints.


Ankylosing spondylitis : In this disorder, the joints between the vertebrae in the spinal column come under attack by the immune system, and cause inflammation.

 

Pharmacokinetics:

Bioavailability 100%

Protein binding 92%

Metabolism

Hepatic, CYP extensively involved (mainly CYP3A4)

Half-life 22 hours


Excretion

Renal (70%) and fecal (20%)


DRUG INTERACTION: 


Before Taking This Tablet Tell The Doctor About Any Medical Problems An Allergies That Child Has Now Or Has Had.


This tablet is the combination of Etoricoxib and Thiocolchicoside and has unique duel mode of action i.e in this combination, etoricoxib used to treat orthopedic and thiocolchicoside used to control the pain and swelling. Drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of etoricoxib and Thiocolchicoside, so the doctor can warn you of any possible drug interactions.


MODE OF ACTION:

After combination of Etoricoxib and Thiocolchicoside we observed that Etoricoxib is selective inhibitor of COX-2 that decreases GI toxicity and is without effects on platelet function. Thiocolchicoside, is a muscle relaxant, which has been claimed to possess GABA (gamma-Aminobutyric acid) mimetic and glycinergic actions. It is used in the symptomatic treatment of painful muscle spasm.


It has been demonstrated by recent studies concomitant administration of an Etoricoxib and Thiocolchicoside shows significantly better symptoms relief compared with the modest improvement of inflammation with each of the treatment alone. 

 

PRECAUTIONS:
Allergic disorders, coagulation defects; history of cardiac failure, left Ventricular dysfunction, hypertension, or in patients with oedema due to other Reasons; elderly, renal, cardiac or hepatic impairment. 

CONTRAINDICATIONS:
Inflammatory bowel disease, Severe congestive heart failure, Active peptic ulceration, Cerebrovascular disease, Lactation Children and adolescent < 16 yr. 

CONCLUSIONS:
From the above discussion, it can be concluded that this tablet is a new combination for a muscle relaxant and displays anti - inflammatory and analgesic properties and could improve the quality of life of adults with pain problem caused by Rheumatoid arthritis and others disorders.


SIDE EFFECTS OF COXINIP-TH TABLET

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

  • Diarrhea

  • Stomach pain

  • Indigestion

  • Flatulence

  • Swelling of hands

  • Feet swelling

  • Flu-like symptoms