Cefuroxime Axetil IP 250 mg
Cefamy is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (e.g. pneumonia), ear, throat, nasal sinus, urinary tract, skin, soft tissues, bones, and joints. It is also used to prevent infections during surgery.
Cefamy 250mg Tablet is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (e.g. pneumonia), ear, throat, nasal sinus, urinary tract, skin, soft tissues, bones, and joints. It is also used to prevent infections during surgery.
Cefamy 250mg Tablet should be taken with food to avoid an upset stomach. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back. It will not work for viral infections such as flu or the common cold. Using any antibiotic when you do not need it can make it less effective for future infections.
The most common side effects of this medicine include rash, vomiting, increased liver enzymes, nausea, and diarrhea. These are usually mild but let your doctor know if they bother you or last more than a few days.
Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. You should also let your doctor know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctor before using it.
Cefuroxime Axetil is a semisynthetic, broad-spectrum cephalosporin antibiotic for oral administration.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefuroxime axetil and other antibacterial drugs, cefuroxime axetil should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Acute Bacterial Otitis Media
Urinary Tract Infections
Lyme Disease (erythema migrans).
Post Surgery infection management
MECHANISM OF ACTION:
Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.
37% on empty stomach,
up to 52% if taken after food,
Urine 66-100% Unchanged
Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi. Cefuroxime axetil is the prodrug.
Absorption: It is absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).
Protein binding: 50% to serum protein.
Metabolism: The Cefamy moiety is metabolized to acetaldehyde and acetic acid.
Half life: It's half life is Approximately 80 minutes following intramuscular or intravenous injection.
SIDE EFFECTS OF CEFAMY TABLET
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Increased liver enzymes